Biologists from the University of Wisconsin-Madison and Italy have discovered that the brightly coloured creatures swimming in the deep ocean of the South Pacific contain some toxins that have the potential to act as potent anti-cancer drugs. Researchers have already identified the structure of these toxins and thus provided a structural basis for the pharmaceutical synthesis of these toxins. The results of the study were published this week in Proceedings of the National Academy of Sciences (PNAS). They studied the interaction of these toxins with actin. The results obtained from the study will help simplify the synthesis of cancer drugs. This type of toxin produced by organisms that coexist with deep-sea sponges acts by interfering with actin activity. Actin forms long filaments (chains) - essential for cell migration. Since cancer cells in the body grow faster than normal cells, actin may be a great target for drugs that inhibit this rapid growth. These marine toxins can destroy key components in these long chains or cover their ends and kill cancer cells. Preliminary studies have shown that these toxins can have a significant effect at low doses. Before the publication of this study, researchers only knew that these marine toxins could affect several types of cancer, but their principle of action was not clear. The new discovery will promote the synthesis of this type of toxin in the laboratory without the need to spend a lot of manpower and resources to collect on the seabed. Organic chemistry experts hope that this type of actin-based drug will be comparable to Taxol's success in the near future. Taxol is a natural compound that inhibits the differentiation of breast cancer cells. Researcher Rayment explained that actin-based drugs have not been a successful drug like micropipettes such as Taxol, partly because people have never known how they target actin. of. The results of the new study laid the foundation for the early use of these new drugs for human cancer treatment.
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