Freeze drying
Freeze drying (referred to as freeze drying) is an advanced drying method. It is based on the heat and mass transfer mechanism under low temperature and low pressure, and freezes the traditional Chinese medicine extract in a low temperature environment below the temperature of the eutectic point of the extract. Then it is placed in a high vacuum environment to make the moisture in the material The ice crystal state is directly sublimated into a gas to remove moisture from the material. Freeze-drying is suitable for the drying of heat-sensitive or easily oxidizable drugs. It has a wide range of applications in the drying process of Chinese herbal medicines. Zui is near, and there are more and more reports on the application of freeze-drying technology to traditional Chinese medicine extracts. Because of the low temperature operation, the freeze-drying process has a large advantage in maintaining the stability of the active ingredient of the extract. The freeze-drying technology is used to solve the traditional limitation that Chinese medicine can not be made into an injection, and solves the problem that Chinese medicine can not be used to treat acute diseases.
The disadvantage of freeze-drying is that the equipment is complicated, the energy consumption is large, and the drying cost is high. Therefore, economy is the bottleneck problem of the application of the technology in the traditional Chinese medicine industry. How to improve the productivity of freeze-drying equipment and reduce energy consumption is the key to the research of freeze-drying technology. There has been some progress in this area of ​​research. It has been reported that increasing the refrigerant temperature of the condenser and using the condenser as a heat source for the heating system can save energy. In addition, better use of microwave heating can improve product quality. The trend in foreign freeze-drying equipment is to replace the empirical freeze-drying cycle with a controlled, verifiable freeze-drying cycle, with a trayless freeze-dried or disposable tray instead of a stainless steel tray for lyophilization.
Freeze-drying has become a branch of engineering technology in the world, and there are specialized research centers for research, and its production equipment is becoming more and more perfect. The development of freeze-drying technology in China in recent years is also very rapid. Beijing Tianli, Beijing Zhongtian Suwon, Shanghai Dongfulong, Zhongmu Nanjing Pharmaceutical Machinery, Shanghai Far East, Shanghai Yucheng Dry and other manufacturers of pharmaceutical freeze dryers, The application can replace the imported similar products, and its automatic lyophilization process, automatic tamping, automatic in-place cleaning and disinfection and sterilization are complete, and the manufacturing quality and automation degree are better. The above companies all passed the IS09001 international quality system. Certification. Among them, Beijing Tianli has obtained CE certification for European products. However, there are still many shortcomings in domestic pharmaceutical freeze dryers. Some manufacturers are still copying products such as British BOCEDWARDS and US STERASFinn-Aqua. In addition, domestic freeze dryers have different standards due to different manufacturers, different technical qualities, different design structures and manufacturing processes.
Freeze drying (referred to as freeze drying) is an advanced drying method. It is based on the heat and mass transfer mechanism under low temperature and low pressure, and freezes the traditional Chinese medicine extract in a low temperature environment below the temperature of the eutectic point of the extract. Then it is placed in a high vacuum environment to make the moisture in the material The ice crystal state is directly sublimated into a gas to remove moisture from the material. Freeze-drying is suitable for the drying of heat-sensitive or easily oxidizable drugs. It has a wide range of applications in the drying process of Chinese herbal medicines. Zui is near, and there are more and more reports on the application of freeze-drying technology to traditional Chinese medicine extracts. Because of the low temperature operation, the freeze-drying process has a large advantage in maintaining the stability of the active ingredient of the extract. The freeze-drying technology is used to solve the traditional limitation that Chinese medicine can not be made into an injection, and solves the problem that Chinese medicine can not be used to treat acute diseases.
The disadvantage of freeze-drying is that the equipment is complicated, the energy consumption is large, and the drying cost is high. Therefore, economy is the bottleneck problem of the application of the technology in the traditional Chinese medicine industry. How to improve the productivity of freeze-drying equipment and reduce energy consumption is the key to the research of freeze-drying technology. There has been some progress in this area of ​​research. It has been reported that increasing the refrigerant temperature of the condenser and using the condenser as a heat source for the heating system can save energy. In addition, better use of microwave heating can improve product quality. The trend in foreign freeze-drying equipment is to replace the empirical freeze-drying cycle with a controlled, verifiable freeze-drying cycle, with a trayless freeze-dried or disposable tray instead of a stainless steel tray for lyophilization.
Freeze-drying has become a branch of engineering technology in the world, and there are specialized research centers for research, and its production equipment is becoming more and more perfect. The development of freeze-drying technology in China in recent years is also very rapid. Beijing Tianli, Beijing Zhongtian Suwon, Shanghai Dongfulong, Zhongmu Nanjing Pharmaceutical Machinery, Shanghai Far East, Shanghai Yucheng Dry and other manufacturers of pharmaceutical freeze dryers, The application can replace the imported similar products, and its automatic lyophilization process, automatic tamping, automatic in-place cleaning and disinfection and sterilization are complete, and the manufacturing quality and automation degree are better. The above companies all passed the IS09001 international quality system. Certification. Among them, Beijing Tianli has obtained CE certification for European products. However, there are still many shortcomings in domestic pharmaceutical freeze dryers. Some manufacturers are still copying products such as British BOCEDWARDS and US STERASFinn-Aqua. In addition, domestic freeze dryers have different standards due to different manufacturers, different technical qualities, different design structures and manufacturing processes.
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