The Agaricus bisporus is one of the mushroom species with the largest cultivation area and the largest transaction volume in the world at present. Its total amount resides in the top of edible fungi, and Hebei, Shandong and other places have formed industrialized production. However, due to the impact of the financial crisis, the export volume of Agaricus bisporus has decreased significantly in the past two years. In addition, the existence of issues such as the awareness and bearing capacity of the domestic market has, to a certain extent, led to the occurrence of the agricultural phenomenon of mushrooming. However, as an international mushroom species, the status of Agaricus bisporus is unshakable. It is hoped that the cultivated area farmers will not lose their confidence due to temporary difficulties, but they should still start with technology, improve the scientific nature of cultivation, and increase production to meet the ever-changing market. . To this end, the newspaper specially invited researchers to write articles to improve the technical level of the majority of mushroom mushroom growers.
(1) The principles of treatment of agaricus base materials: balanced nutrition, scientific fermentation, uniform maturity, no pests.
2. Base formulation: wheat straw (or straw) 3000 kg, cow dung powder 3000 kg, superphosphate 60 kg, urea 40 kg, lime powder 80 kg, gypsum powder 80 kg, calcium carbonate 90 kg, Saibai 09 drug 1500 Grams and Edible Fungus 3D Nutrient (14kg) (12 bags). The formula maximizes the overall balance of the nutrition of the base material, making the hyphae of mycelium robust, and maximizing the amount of biotransformation. In addition to the raw and auxiliary materials mentioned above, corn cobs, corn stalks, cottonseed hulls, bacillary dysentery, biogas residue, chicken manure, and pig manure can all be used as cultivation materials.
3. Requirements for raw and auxiliary materials: All raw materials need to be fresh and free of mildew. Wheat straw and rice straw should be dried in time during the crop harvesting season. Corn cobs should be crushed; cow dung should be spread out; , Knocking, so that it is quickly crushed powder state, and then sieve once, will be more than 1 cm of fecal pellets to re-crush, the final cow dung into powder; fresh chicken manure, pig dung, etc. fully dried, then press 10% Proportional addition of biological starter to carry out stacking fermentation. When there is no starter, 2% lime powder, 2% superphosphate or calcium magnesium phosphate fertilizer can be added. Mix the water with the ratio of manure to water around 1:1 and build a heap fermentation. About 2 to 3 weeks, when the feces heap is full of white actinomycetes, the volume-to-weight ratio is significantly reduced, and the odor is greatly reduced, the exposure can be spread and dried. Gypsum powder may be raw and cooked, but the price of raw gypsum is appropriate; lime powder should be fresh powder after decomposing quicklime. It can be used too long, and water content is too high, but it should be increased according to the circumstances.
4. Fermentation treatment: (1) Pre-wetting and building a heap: Pre-wet the wheat straw directly with water and keep it for 2 days so that it is thoroughly soaked thoroughly. Straw, corn stalks, corn cobs, etc. are treated as such; cottonseed husks, mash waste, can be mixed with water in the 2 to 4 hours before the heap fermentation.
In addition to three-dimensional sperm, all raw and auxiliary materials are used for building heap fermentation. The way is a layer of grass, a layer of cow dung (chicken manure, etc.) and accessories, stacked layers. When the general building piles, there should be surplus cow dung, not all paved in the material should be at the top of the pile with a pile of cow dung from a pile of spires, so that the rain, blocking the material pile heat up excessive dissemination. The thermometer is inserted into the stock at a height of 1 meter to a height of 40 cm to monitor the temperature of the material.
(2) One-time fermentation: starting from the date of self-built heap, it is turned over once a day for 5 times in total. The purpose is to change the position of each fermentation area in the stockpile, especially for the last fermentation of edge material, bottom material, and top material. During the process, the base material with a low temperature level is turned into a high-temperature fermentation zone where it is subjected to high temperatures and is fully fermented, thereby changing its physical and chemical properties, so that nutrition can be effectively decomposed and transformed. The method of turning the piles is to spray water on the stack several hours in advance so that the marginal forage can be fully absorbed. When the stack is turned, the top cow dung is first plucked down; from the end of the stack, the edge material is taken off first, the high temperature area inside the pile is used as the bottom and top of the new material pile, and the edge material, the bottom material and the top material are turned over. Into the middle of the new stockpile. The procedure for building a new reactor is still the same as for the first time. The cow dung is laid on top of the floor. It is worth noting that during the turning process, the excrement of cow dung from the raw material pile has been difficult to completely remove and re-ply. Only distribute it as uniformly as possible in each layer. Turn over from the second floor to the appropriate time for replenishment. Each replenishment amount depends on the water content of the raw material. It is preferable to use the wet and not seepage flow to avoid nutrient loss. The second turn method is the same as above. At the third turn of the pile, the 800-fold phoxim solution was sprayed evenly into each layer of material at an amount of about 50 kg per 1,000 kg of dry material in order to drive off pests in the material pile. At the last turn, the moisture content of the base material was adjusted, and the three-dimensional semolina was uniformly sprayed in. After two days, the temperature was spread and cooled, and the moisture content was adjusted to about 65%, the pH value was about 8, and the temperature was cooled to below 30°C or room temperature. Can be planted into the shed.
Ziprasidone Intermediates
Ziprasidone is a medication of the atypical antipsychotic type. It is used for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder. Its intramuscular injection form is approved for acute agitation in people with schizophrenia. Ziprasidone is also used off-label for depression, bipolar maintenance, and posttraumatic stress disorder.
Ziprazidone is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder. Its intramuscular injection form is approved for acute agitation in schizophrenic patients for whom treatment with just ziprasidone is appropriate.
We produce a series of complete intermediates for Ziprasidone, intermediate I (CAS No. 2634-33-5) and intermediate II (CAS No. 7716-66-7) etc.
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Ziprasidone Intermediates
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