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Doxorubicin Hydrochloride SpecificationProduct Name: Doxorubicin Hydrochloride
CAS: 25316-40-9
Standard: USP
Natural/Synthetic: Natural
Level: Pharmaceutical grade
Content: 99%
Appearance: orange red powder
Packing: 100g/aluminum foil bag
Ingredients: Adriamycin hydrochloride Chinese name: Doxorubicin hydrochloride Chinese name: Doxorubicin hydrochloride CAS: 25316-40-9 Molecular formula: C27H30ClNO11 Molecular weight: 579.98 EINECS number: 246-818-3
Physicochemical properties: The hydrochloride is orange needle-like crystals with a melting point of 204-205°C. Soluble in water and alcohol, insoluble in acetone, benzene, chloroform, ether. Doxorubicin is an antitumor antibiotic that inhibits the synthesis of RNA and DNA, has the strongest inhibitory effect on RNA, has a broad spectrum of antitumor activity, and has a role in many kinds of tumors. Cycle tumor cells have a killing effect
Category: Pharmaceutical Raw Materials
Field: Antineoplastic Agents
Deferred products: doxorubicin is an antitumor antibiotic, doxorubicin liposomes, tablets, etc.
Use: For the treatment of acute lymphoblastic leukemia, acute myelogenous leukemia, Hodgkin's disease and non-Hodgkin's disease lymphoma, breast cancer, lung cancer, ovarian cancer
Usage and dosage: Before use, disinfect it with sterile water for injection 5ml, 25ml, then add 5% glucose injection or sterile saline. Intravenous injection or infusion, commonly used amount of 40-60mg per square meter of surface area for a course of treatment, generally administered at intervals, three weeks for a course of treatment, the specific usage is as follows: 1. A 10mg, once daily, 4-8 days in a row, 7-10 days of withdrawal, more than one course of treatment, continuous administration of 2-3 courses. 2. A 20mg, once daily, continuous 2-3 days, withdrawal 7-10 days, the above is a course of treatment, continuous administration of 2-3 courses. 3. Once 20-30mg once a day for 3 days, stopping for 18 days. The above is a course of treatment that can be administered continuously for 2-3 courses.
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What is Doxorubicin Hydrochloride?Doxorubicin Hydrochloride is a cytotoxic, anthracycline, topoisomerase II inhibitor.
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| Product name | Doxorubicin Hydrochloride | |||
| CAS No. | 25316-40-9 | Outer Packing | 100g/bag | |
| Production date | 2017-12-08 | Shelf life | 2 years | |
| Standard adopted | USP36 | |||
| Items of analysis | Specification | Results | ||
| Appearance | Orange-red crystalline powder | Orange-red crystalline powder | ||
| Chlorides Identification | Identification (HPLC) | Conforms | ||
| Identification (UV) | Conforms | |||
| Identification (IR) | Conforms | |||
| Chlorides Identification | Conforms | |||
| Crystallinity | Conrorms | Conforms | ||
| Acidity | 4.5-5.5 | 5.1 | ||
| Related Substances | single lmpurity | 0.4% | ||
| Residual Solvents | Methanol | 0.018% | ||
| Water | ≤4.0% | 1.5% | ||
| Endotoxin | <2.0EU/ mg | -- | ||
| Assay | C27H29NO11.HCI ≥ 98.0%~102.0%(on the anhydrous , Solvent-free basis) | 100.0% | ||
| Conclusion | Qualified | |||
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