Release date: 2015-07-06
July 3, 2015 - In a recent study published in the international journal Nature Structural & Molecular Biology , researchers from Duke University have achieved breakthrough results in the field of HIV research through research and development. A 3D "designer" protein, once injected into the body of an HIV patient, helps the patient's immune system to better produce antibodies against HIV.
At present, more than 35 million people worldwide are infected with HIV, and 2 million people die of AIDS every year. Once an individual is infected with HIV, antiretroviral drugs can inhibit the replication of infected organisms, but only vaccines can block HIV in different individuals. The spread of vaccines can prevent viral infections by inducing the body's immune system to produce antibody proteins. These antibodies help the body to resist foreign viruses. However, in the body of HIV patients, viruses always "cheat" the body to survive and proliferate.
HIV can incorporate its genetic material into the DNA of the host cell, which intercepts the host cell's replication machinery and drives the replication machine to help create more copies of the virus. As early as the 1990s, researchers discovered a portion of HIV-infected Specific antibodies are produced in the body of the individual to help their body resist the invasion of different strains. This broad-spectrum neutralizing antibody is immobilized on the surface of the virus, just like a lock and a key, so that the antibody inhibits the virus from infecting other cells.
However, HIV often uses these antibodies to evade the body's monitoring, because the outer membrane that is very sensitive to the attack on the surface of HIV will constantly change its shape; in order to overcome this problem, the researchers in this study have a spike on the surface of HIV called Env. Proteins were studied, and with the help of 3D printing technology, the researchers developed a scoring system and developed a series of nominal amounts of antibodies based on the combination of antibodies and viruses. The researchers said that we identified the Env protein. The special conformation can help find effective antibodies and antibodies that have no effect.
The researchers then identified specific amino acid sequence changes that could effectively silence the expression of the protein in the ideal shape of the Env protein; the researchers said that once the Env protein is injected into the patient's body, it will induce the body's immune system to be most effective. Antibody; the last researcher, Donald, said that our idea is to lock the Env protein so that it does not transition to other conformational states, allowing effective antibodies to bind to it, ultimately inhibiting the spread of HIV.
Source: Bio Valley
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