High Quality Pharmaceutical Intermediates Ketotifen Fumarate CAS 34580-14-8 for Antiasthmatic

High Quality Pharmaceutical Intermediates Ketotifen Fumarate CAS 34580-14-8 for Antiasthmatic


Brief introduction:
 



Chemical Properties: This product is white (or light-yellow) crystalline powder, and is odorless with bitter taste. It is slightly soluble in water and ethanol, and easily soluble in methanol but very slightly soluble in chloroform and acetone.

Ketotifen fumarate Description:

Ketotifen fumarate is a kind of strong anti-allergic drugs containing simultaneously of both tricyclic structure as well as piperidine structure. It is characterized by both a strong antagonism effect on histamine H1 receptor and inhibitory effect of the release of the mediator of allergic reaction. 

It can inhibit the release various kinds of mediators of mast cells, basophils and macrophages, including the release of slow reacting substances and other active substances. 


Usage: 

1. Antihistamines, antiasthmatic, used for the prevention, treatment of bronchitis asthma. 
2. Department of Dermatology, urticaria, pruritus, eczema, for allergic dermatitis, atopic dermatitis, neurodermatitis and other allergic diseases; Recent reports of scleroderma treated effectively. Department of internal medicine has good curative effect on bronchial asthma, has significant therapeutic effect on allergic asthma, mixed type, infective about half effective, have a preventive effect on asthma. 

Pharmacological effects:

1. Antagonizing effect on inflammatory mediators: Clinical studies have already demonstrated that ketotifen fumarate can effectively inhibit the histamine-induced bronchospasm with its intensity being comparable to Azelastine, suggesting that ketotifen fumarate has strong histamine antagonistic effect. Modern studies have shown that ketotifen fumarate may also other inflammatory mediators such as antagonize leukotrienes and platelet activating factor. From this perspective, it is considered that ketotifen is a drug which can antagonize a variety of inflammatory mediators. This may be the primary mechanism for its prevention and treatment of asthma as well as childhood asthma. 

2. The membrane protective effect of mast cells/basophils: the related pharmacological studies of ketotifen fumarate have confirmed that it can inhibit mast cell /basophil cells to release inflammatory mediators such as histamine, leukotrienes and platelet activating factor, suggesting that it has a strong membrane protective effects on mast cells/basophils membrane. This may be the major mechanism underlying the dual property of ketotifen fumarate for being able to both prevent and treat the asthma and childhood asthma. 

3. The inhibition of airway inflammatory cell infiltration: fumarate ketotifen can inhibit the infiltration of the airways of eosinophil and neutrophil. However, the mechanism remains to be unclear. 

4. Regulation of T cell activity: ketotifen fumarate can inhibit the biosynthesis of intracellular lgE through regulating the release activity of CD4 + and CD8 + lymphocytes. The mechanisms of inhibition of the biosynthesis of lgE and the above two mechanisms determines the airway anti-inflammatory effects of ketotifen fumarate.

5. Other effects: Some studies have suggested that ketotifen fumarate can reverse the low-regulation of beta2-receptor caused by the long-term administration of beta2-receptor agonist and also increase the density of airway beta2-receptor as well as enhance the effect of beta2-receptor. Some studies have also suggested that ketotifen fumarate also having blocking effect on the calcium channels. 

Clinical application:

It has been more than 20 years since ketotifen fumarate have been applied to the prevention and treatment of asthma and childhood asthma. It is a kind of drug with dual effect of both prevention and treatment in the prevention and treatment of asthma and childhood asthma. 

It should be particularly noted that ketotifen had ever taken as the long-term controlling drug of asthma and childhood long-term asthma and was subject to wide application in many countries. Since the early 1980s, ketotifen fumarate had already been applied in Western Europe, Asia, and China for the prevention and treatment of asthma and asthma in children.

Ketotifen fumarate Side effect:

The most severe side effect of ketotifen fumarate is its inhibitory effect on central nerve system such as causing sleepiness or fatigue, weakness. This side effect is more significant in adults and is one of the major reasons for limiting its clinical application. The resulted sense of lethargy or fatigue, weakness may reduce the life quality of asthma patients as well as children with asthma.

 

Product Packaging

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

Storage

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery

Usually within 3-7 working days after payment.

Shipping

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Service

we will try our best to satisfied you.
1. Tailor-made for every customers. 
2. Third-party test for the products you demand. 
3. Test your counter-samples and produce them for you. 
4. Best discount for old customers. 
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply & service.
11. Strictly on selecting raw materials.

After-Sale Service

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.
 

The quality control process

1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

Process and Advice:
 


Our Advantages

1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .

3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .

4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.

5. Fast delivery:we have stock, so we can delivery quickly once payment is received.

6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.

7. Competitive prices:A discount would be given when you make a large order.


Please feel free to contact me if you need any further information~







  High Quality Pharmaceutical Intermediates Ketotifen Fumarate CAS 34580-14-8 for Antiasthmatic


Brief introduction:
 



Chemical Properties: This product is white (or light-yellow) crystalline powder, and is odorless with bitter taste. It is slightly soluble in water and ethanol, and easily soluble in methanol but very slightly soluble in chloroform and acetone.

Ketotifen fumarate Description:

Ketotifen fumarate is a kind of strong anti-allergic drugs containing simultaneously of both tricyclic structure as well as piperidine structure. It is characterized by both a strong antagonism effect on histamine H1 receptor and inhibitory effect of the release of the mediator of allergic reaction. 

It can inhibit the release various kinds of mediators of mast cells, basophils and macrophages, including the release of slow reacting substances and other active substances. 


Usage: 

1. Antihistamines, antiasthmatic, used for the prevention, treatment of bronchitis asthma. 
2. Department of Dermatology, urticaria, pruritus, eczema, for allergic dermatitis, atopic dermatitis, neurodermatitis and other allergic diseases; Recent reports of scleroderma treated effectively. Department of internal medicine has good curative effect on bronchial asthma, has significant therapeutic effect on allergic asthma, mixed type, infective about half effective, have a preventive effect on asthma. 

Pharmacological effects:

1. Antagonizing effect on inflammatory mediators: Clinical studies have already demonstrated that ketotifen fumarate can effectively inhibit the histamine-induced bronchospasm with its intensity being comparable to Azelastine, suggesting that ketotifen fumarate has strong histamine antagonistic effect. Modern studies have shown that ketotifen fumarate may also other inflammatory mediators such as antagonize leukotrienes and platelet activating factor. From this perspective, it is considered that ketotifen is a drug which can antagonize a variety of inflammatory mediators. This may be the primary mechanism for its prevention and treatment of asthma as well as childhood asthma. 

2. The membrane protective effect of mast cells/basophils: the related pharmacological studies of ketotifen fumarate have confirmed that it can inhibit mast cell /basophil cells to release inflammatory mediators such as histamine, leukotrienes and platelet activating factor, suggesting that it has a strong membrane protective effects on mast cells/basophils membrane. This may be the major mechanism underlying the dual property of ketotifen fumarate for being able to both prevent and treat the asthma and childhood asthma. 

3. The inhibition of airway inflammatory cell infiltration: fumarate ketotifen can inhibit the infiltration of the airways of eosinophil and neutrophil. However, the mechanism remains to be unclear. 

4. Regulation of T cell activity: ketotifen fumarate can inhibit the biosynthesis of intracellular lgE through regulating the release activity of CD4 + and CD8 + lymphocytes. The mechanisms of inhibition of the biosynthesis of lgE and the above two mechanisms determines the airway anti-inflammatory effects of ketotifen fumarate.

5. Other effects: Some studies have suggested that ketotifen fumarate can reverse the low-regulation of beta2-receptor caused by the long-term administration of beta2-receptor agonist and also increase the density of airway beta2-receptor as well as enhance the effect of beta2-receptor. Some studies have also suggested that ketotifen fumarate also having blocking effect on the calcium channels. 

Clinical application:

It has been more than 20 years since ketotifen fumarate have been applied to the prevention and treatment of asthma and childhood asthma. It is a kind of drug with dual effect of both prevention and treatment in the prevention and treatment of asthma and childhood asthma. 

It should be particularly noted that ketotifen had ever taken as the long-term controlling drug of asthma and childhood long-term asthma and was subject to wide application in many countries. Since the early 1980s, ketotifen fumarate had already been applied in Western Europe, Asia, and China for the prevention and treatment of asthma and asthma in children.

Ketotifen fumarate Side effect:

The most severe side effect of ketotifen fumarate is its inhibitory effect on central nerve system such as causing sleepiness or fatigue, weakness. This side effect is more significant in adults and is one of the major reasons for limiting its clinical application. The resulted sense of lethargy or fatigue, weakness may reduce the life quality of asthma patients as well as children with asthma.

 

Product Packaging

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

Storage

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery

Usually within 3-7 working days after payment.

Shipping

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Service

we will try our best to satisfied you.
1. Tailor-made for every customers. 
2. Third-party test for the products you demand. 
3. Test your counter-samples and produce them for you. 
4. Best discount for old customers. 
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply & service.
11. Strictly on selecting raw materials.

After-Sale Service

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.
 

The quality control process

1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

Process and Advice:
 


Our Advantages

1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .

3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .

4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.

5. Fast delivery:we have stock, so we can delivery quickly once payment is received.

6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.

7. Competitive prices:A discount would be given when you make a large order.


Please feel free to contact me if you need any further information~







 

EURO Cap

This product is suitable for packaging of infusion medicine in pharmaceutical industry. It is produced in a clean plant which meets the GMP standard. Our main working procedures are strictly obey the operating rules which can meet the cleaning requirements that the industry need.Also the facilities we used in the whole process are under a standard management in our factory, we will keep regular inspection and cleaning each week to make sure qualified products.

EURO BFS Cap, Plastic Cap, PE Assembled Cap, Bfs Cap For Iv Solution Bottles

Suzhou CRH New Material Technology Co.,Ltd. , https://www.crh-health.com